OxLDL induces endothelial dysfunction and death via TRAF3IP2: Inhibition by HDL3 and AMPK activators
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G9a Inhibition Induces Autophagic Cell Death via AMPK/mTOR Pathway in Bladder Transitional Cell Carcinoma
G9a has been reported to highly express in bladder transitional cell carcinoma (TCC) and G9a inhibition significantly attenuates cell proliferation, but the underlying mechanism is not fully understood. The present study aimed at examining the potential role of autophagy in the anti-proliferation effect of G9a inhibition on TCC T24 and UMUC-3 cell lines in vitro. We found that both pharmaceutic...
متن کاملoxLDL induces endothelial cell proliferation via Rho/ROCK/Akt/p27 signaling: opposite effects of oxLDL and cholesterol loading
Zhang C, Adamos C, Oh MJ, Baruah J, Ayee MA, Mehta D, Wary KK, Levitan I. oxLDL induces endothelial cell proliferation via Rho/ROCK/Akt/p27 signaling: opposite effects of oxLDL and cholesterol loading. Am J Physiol Cell Physiol 313: C340 –C351, 2017. First published July 12, 2017; doi:10.1152/ ajpcell.00249.2016.—Oxidized modifications of LDL (oxLDL) play a key role in the development of endoth...
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Oxidized modifications of LDL (oxLDL) play a key role in the development of endothelial dysfunction and atherosclerosis. However, the underlying mechanisms of oxLDL-mediated cellular behavior are not completely understood. Here, we compared the effects of two major types of oxLDL, copper-oxidized LDL (Cu2+-oxLDL) and lipoxygenase-oxidized LDL (LPO-oxLDL), on proliferation of human aortic endoth...
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Aldosterone is traditionally viewed as a hormone regulating electrolyte and blood pressure homeostasis. Recent studies suggest that Aldo can cause microvascular damage, oxidative stress and endothelial dysfunction. However, its exact cellular mechanisms remain obscure. This study was undertaken to examine the effect of Aldo on superoxide production in human umbilical artery endothelial cel...
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BACKGROUND/AIMS The immunosuppressive drug tacrolimus (FK506) is used clinically to reduce the rejection rate in patients with kidney transplantation; however, the resultant nephrotoxicity remains a serious problem. In the present study we attempted to elucidate the mechanisms of glomerular injury induced by FK506 and the renoprotective effects of the angiotensin II receptor blocker telmisartan...
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ژورنال
عنوان ژورنال: Free Radical Biology and Medicine
سال: 2014
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2014.02.014